i-Factor

Mandag, 23. maj 2011 12:23

i-FACTOR™ Bone Graft Technology     

i-FACTOR™ Bone Graft is the only biologic bone graft that utilizes a synthetic small peptide (P-15™) bound to anorganic bone mineral (ABM). This unique ABM/P-15 combination acts as an attachment factor for osteogenic cells.

The first step in the bone formation process is cell attachment. Osteogenic precursor cells bind to P-15 via their α2β1 integrins, which are signaling receptors.

  • i-FACTOR increases the opportunity for cell binding in the fusion site by making an abundance of P-15 available to osteogenic precursor cells, resulting in enhanced cell attachment.
  • After osteogenic precursor cells attach to ABM/P-15 via their α2β1 integrins, a natural signaling cascade occurs that leads to new bone formation. i-FACTOR will only stimulate a healing response in the presence of bone forming cells.
  • This novel mechanism of action enhances the body's natural bone healing process resulting in safe, predictable bone formation.


How i-FACTOR™ Bone Graft Works

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P-15™ Stimulates Natural Healing

i-FACTOR technology is based on the biological activity of a synthetically derived 15-amino acid peptide found naturally in Type I human collagen. Type I human collagen is the primary organic component of autograft bone. This 15-amino acid peptide (P-15) is responsible for the attachment and proliferation of osteogenic cells. These cells attach to the synthetic P-15 found in i-FACTOR in a similar way they would attach to Type I collagen.

Unlike many growth factors, P-15 will only stimulate a healing response in the presence of bone forming cells. This natural healing response leads to safe, predictable bone formation.

 

The Bone Healing Process

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